p53 p21

p53 p21·相關網站分享資訊

  • p53腫瘤抑制蛋白(p53 tumor suppressor protein) - 小小整理網站 ...

    smallcollation.blogspot.com

    p53蛋白在避免癌症發生機制上扮演重要的角色，例如：細胞凋亡(apoptosis) 、基因組穩定性(genetic stability) 、抑制血管新生(angiogenesis)。 p53蛋白通過下列之機構 ... 活化的p53蛋白能接合於DNA，促使多個基因表現，包括基因WAF1/CIP1，其為p21蛋白之編碼基因。 p21 (WAF1)接合於G1-S/CDK (CDK2)和S/CDK複合體(此蛋白 ...

  • p53 - 维基百科，自由的百科全书

    zh.wikipedia.org

    活化的p53蛋白能接合於DNA，促使多個基因表現，包括基因WAF1/CIP1，其為p21蛋白之編碼基因。 p21 (WAF1)接合於G1-S/CDK (CDK2) 和S/CDK複合體(此蛋白在G1/S細胞週期節律點上有重要功能) 以抑制該複合體的活性。 當p21蛋白(WAF1) 與CDK2形成複合體時，細胞將無法進入到細胞分裂的階段。 而突變後的p53蛋白將可能 ...

  • p21 - Wikipedia

    en.wikipedia.org

    跳到 p53 dependent response - Studies of p53 dependent cell cycle arrest in response to DNA damage identified p21 as the primary mediator of ...

  • Induction of p21 by p53 following DNA damage inhibits ... - NCBI - NIH

    www.ncbi.nlm.nih.gov

    2005年4月21日 - DNA damage often activates the p53-p21 pathway and causes G(1)-phase arrest in mammalian cells. Although there is ample evidence that ...

  • The p53/p21 Complex Regulates Cancer Cell Invasion and Apoptosis ...

    www.ncbi.nlm.nih.gov

    Cancer Res. 2017 Jun 1;77(11):3092-3100. doi: 10.1158/0008-5472.CAN-16-2098. Epub 2017 Apr 4. The p53/p21 Complex Regulates Cancer Cell Invasion ...

  • Differential regulation of p21 by p53 and Rb in cellular response to ...

    www.ncbi.nlm.nih.gov

    Mol Carcinog. 1999 Jan;24(1):15-24. Differential regulation of p21 by p53 and Rb in cellular response to oxidative stress. Yin Y(1), Solomon G, Deng C, Barrett ...

  • Relationship between p21 expression and mutation of the p53 tumor ...

    www.ncbi.nlm.nih.gov

    Clin Cancer Res. 1996 Sep;2(9):1571-5. Relationship between p21 expression and mutation of the p53 tumor suppressor gene in normal and malignant ovarian ...

  • Induction of p21 by p53 following DNA damage inhibits both ... - Nature

    www.nature.com

    2005年2月7日 - DNA damage often activates the p53–p21 pathway and causes G1-phase arrest in mammalian cells. Although there is ample evidence that ...

  • p53-dependent gene repression through p21 is mediated by ... - Nature

    www.nature.com

    2013年10月7日 - The best known examples of such targets include p21 and MDM2. More than one hundred p53 direct transcriptional targets have so far been ...

  • Tumorsuppressorgen - Wikipedia

    nl.wikipedia.org

    Een tumorsuppressorgen is een gen dat onbeperkte deling van de cel voorkomt en daarmee het ontstaan van een tumor verhindert. Het eiwit dat door dit gen gecodeerd wordt, heeft namelijk een negatieve invloed op de celdeling. Tegenover een tumorsuppressorge